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Debaryomyces hansenii

Species biology: Debaryomyces hansenii is a marine yeast that occurs globally with extreme tolerance to salt/dehydration stress. It is slightly salt-stimulated and grows better under salt levels in the range of sea-water. Its adaptation to salt also makes it frequent in salt-conserved foods. It is a unicellular free-living organism that mostly occurs in an asexually reproducing haploid state. The genome for the type strain was completed in 2004.

Rationale for developing this model: We will generate a unique resource for experimental work in this marine yeast-species to enable studies that will lead to a better understanding of the genetic basis of salinity adaptation. The completed genome opens up for global studies on gene expression and comparative studies of mechanistic differences in its molecular response in relation to the model yeast S. cerevisiae, as well as other sequenced yeast species. Studies on D. hansenii will be central in our understanding of evolution of osmoregulation in marine fungi

Key references: Dujon et al., (2004) Genome evolution in yeasts
Nature 430:35, Adler, L., Blomberg, A. and Nilsson, A. (1985) Glycerol Metabolism and Osmoregulation in the Salt-tolerant Yeast Debaryomyces hansenii. Journal of Bacteriology. 162:300

Estimated Genome size: 0.0138 Gbp

Available sequence information: -

Genome sequencing progress: (last updated 2016-08-25)
Population resequencing, 17 strains
DNA Libraries, bp - 150

Additional genetic resources: We are currently establishing the methodology for making gene-deletions in D. hansenii. A collection of strains carrying gene-deletions in osmoregulatory genes will be constructed.

Other resources: One of the strains, J26, originally isolated by Birgitta Norkrans, Kungsbackafjorden 1965, is highly studied for its physiological responses during salt-stress. D. hansenii strains is phenotyped for growth changes under a wide array of conditions, in particular in relation to osmo- and salt-stress. Phenotypic information will be displayed on our local phenotypic database PROPHECY.

In culture: Yes; several individual isolates of D. hansenii in stock (frozen -80). All isolates are in the process of being sequenced.

Contact: Anders Blomberg - anders.blomberg@marine.gu.se
Bioinformatician: Tomas Larsson - tomas.larsson@marine.gu.se

IMAGO marine model species
Page Manager: Eva Marie Rödström|Last update: 8/25/2016
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